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Elucidation of the mechanism of action of ailanthone in the treatment of colorectal cancer: integration of network pharmacology, bioinformatics analysis and experimental validation

Background: Ailanthone, a small compound derived from the bark of Ailanthus altissima (Mill.) Swingle, has several anti-tumour properties. However, the activity and mechanism of ailanthone in colorectal cancer (CRC) remain to be investigated. This study aims to comprehensively investigate the mechan...

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Principais autores: Shanbo Ma, Xiaodi Guo, Ruisi Han, Qian Meng, Yan Zhang, Wei Quan, Shan Miao, Zhao Yang, Xiaopeng Shi, Siwang Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-02-01
Colecção:Frontiers in Pharmacology
Assuntos:
ailanthone
colorectal cancer
network pharmacology
bioinformatic
PI3K/AKT
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2024.1355644/full
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