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Pathophysiologic and transcriptomic analyses of viscerotropic yellow fever in a rhesus macaque model.

Infection with yellow fever virus (YFV), an explosively replicating flavivirus, results in viral hemorrhagic disease characterized by cardiovascular shock and multi-organ failure. Unvaccinated populations experience 20 to 50% fatality. Few studies have examined the pathophysiological changes that oc...

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Principais autores: Flora Engelmann, Laurence Josset, Thomas Girke, Byung Park, Alex Barron, Jesse Dewane, Erika Hammarlund, Anne Lewis, Michael K Axthelm, Mark K Slifka, Ilhem Messaoudi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS Neglected Tropical Diseases
Online adgang:http://europepmc.org/articles/PMC4238990?pdf=render
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