Research progress of tertiary lymphoid structure in hepatocellular carcinoma: from prognostic biomarkers to new strategies for immunotherapy

Tertiary lymphoid structures (TLS) are important ectopic immune aggregates that develop within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC) and have attracted increasing attention due to their potential clinical value. Recent studies have identified TLS as key players in progno...

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Bibliographic Details

Main Authors:	Shimin Yuan, Xianting Luo, Shu Li, Long Cao, Xiang Chen, Ling Wang, Yan Liu, Zipeng Li, Tongnuo Wu, Hongcai Fang, Mingfu Tong
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Immunology
Subjects:	hepatocellular carcinoma immunotherapy biomarker non-invasive testing tertiary lymphoid structure tumor immune microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1741542/full
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