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GM-CSF-dependent CD301b+ mouse lung dendritic cells confer tolerance to inhaled allergens

Abstract The severity of allergic asthma is driven by the balance between allergen-specific T regulatory (Treg) and T helper (Th)2 cells. However, it is unclear whether specific subsets of conventional dendritic cells (cDCs) promote the differentiation of Tregs. We have identified a subset of lung r...

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Uloženo v:
Hlavní autoři: Christina L. Wilkinson, Keiko Nakano, Sara A. Grimm, Gregory S. Whitehead, Yukitomo Arao, Perry J. Blackshear, Peer W. Karmaus, Michael B. Fessler, Donald N. Cook, Hideki Nakano
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-09-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-63547-3
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