AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
The endoplasmic reticulum (ER)-localized Hsp70 chaperone BiP contributes to protein folding homeostasis by engaging unfolded client proteins in a process that is tightly coupled to ATP binding and hydrolysis. The inverse correlation between BiP AMPylation and the burden of unfolded ER proteins sugge...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
eLife Sciences Publications Ltd
2017-10-01
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| سلاسل: | eLife |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://elifesciences.org/articles/29428 |
| الوسوم: |
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