Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related neurodegenerative deficits

Abstract One key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize catecholamines. Neurons reachi...

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Detalhes bibliográficos

Principais autores:	Ariadna Laguna, Núria Peñuelas, Marta Gonzalez-Sepulveda, Alba Nicolau, Sébastien Arthaud, Camille Guillard-Sirieix, Marina Lorente-Picón, Joan Compte, Lluís Miquel-Rio, Helena Xicoy, Jiong Liu, Annabelle Parent, Thais Cuadros, Jordi Romero-Giménez, Gemma Pujol, Lydia Giménez-Llort, Patrice Fort, Analia Bortolozzi, Iria Carballo-Carbajal, Miquel Vila
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-10-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-024-53168-7
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