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Human PC4 supports telomere stability and viability in cells utilizing the alternative lengthening of telomeres mechanism

Abstract Cancer cells with an activated Alternative Lengthening of Telomeres (ALT) mechanism elongate telomeres via homology-directed repair. Sustained telomeric replication stress is an essential trigger of ALT activity; however, it can lead to cell death if not properly restricted. By analyzing pu...

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Wedi'i Gadw mewn:
Prif Awduron: Sara Salgado, Patricia L Abreu, Beatriz Moleirinho, Daniela S Guedes, Lee Larcombe, Claus M Azzalin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Nature 2024-10-01
Cyfres:EMBO Reports
Pynciau:
Alternative Lengthening of Telomeres
Cancer
PC4/Sub1
Replications Stress
Mynediad Ar-lein:https://doi.org/10.1038/s44319-024-00295-3
Tagiau: Ychwanegu Tag
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