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Identifying the Naphthalene-Based Compound 3,5-Dihydroxy 2-Napthoic Acid as a Novel Lead Compound for Designing Lactate Dehydrogenase-Specific Antibabesial Drug

Human babesiosis is caused by apicomplexan Babesia parasites, including Babesia microti, Babesia crassa, Babesia sp. MOI, Babesia divergens, Babesia duncani, and Babesia venatorum. Among them, B. microti is the most common cause of human and rodent babesiosis. Currently, no vaccine is available, and...

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Principais autores: Long Yu, Xueyan Zhan, Qin Liu, Yali Sun, Muxiao Li, Yangnan Zhao, Xiaomeng An, Yu Tian, Lan He, Junlong Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-01-01
coleção:Frontiers in Pharmacology
Assuntos:
Babesia microti
lactate dehydrogenase
naphthalene-based compound
human babesiosis
growth inhibition
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphar.2019.01663/full
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