Glymphatic dysfunction and neuroinflammation in FXTAS: evidence from DTI-ALPS and gene expression analysis

Background and objectivesFragile X–associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder that affects carriers of the FMR1 premutation (55–200 CGG repeats). It is characterized by motor and cognitive impairments. However, the mechanisms underlying individual susceptibi...

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Prif Awduron:	Andrea Elias-Mas, Esther Granell Moreno, Cèlia Painous Martí, Marta Rubio-Roy, Jorge Aguado-Gracia, Emma Muñoz-Moreno, Alejandro Hinojosa, Iñigo Herrero, Maria Isabel Alvarez-Mora, Randi Hagerman, Jun Yi Wang, Idoia Zaro, Sofia González Ortiz, Jerzy Krupinski, Laia Rodriguez-Revenga
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2026-05-01
Cyfres:	Frontiers in Molecular Neuroscience
Pynciau:	DTI-ALPS index FMR1 premutation FXTAS gene dysregulation gene expression glymphatic
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fnmol.2026.1856101/full
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