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Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

Abstract Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cell generation. We have recently demonstrated the gen...

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Principais autores: Idil I. Aigha, Bushra Memon, Ahmed K. Elsayed, Essam M. Abdelalim
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-04-01
Serier:Stem Cell Research & Therapy
Fag:
hESCs
hiPSCs
Pancreatic development
Transcription factors
Pancreatic progenitors
β cells
Online adgang:http://link.springer.com/article/10.1186/s13287-018-0834-0
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