AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions

Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. Results As a proof of principle, we show in both cell...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy, Vincent Ollendorff
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2020-07-01
Цуврал:	BMC Biology
Нөхцлүүд:	mTor signaling mTORC1 Biosensor BRET Muscle differentiation mToropathies Neuronal activity
Онлайн хандалт:	http://link.springer.com/article/10.1186/s12915-020-00790-8
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!