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KDM5B predicts temozolomide-resistant subclones in glioblastoma

Summary: Adaptive plasticity to the standard chemotherapeutic temozolomide (TMZ) leads to glioblastoma progression. Here, we examine early stages of this process in patient-derived cellular models, exposing the human lysine-specific demethylase 5B (KDM5B) as a prospective indicator for subclonal exp...

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Auteurs principaux: Vivien Ullrich, Sarah Ertmer, Anna Baginska, Madeleine Dorsch, Hanah H. Gull, Igor Cima, Pia Berger, Celia Dobersalske, Sarah Langer, Loona Meyer, Philip Dujardin, Sied Kebir, Martin Glas, Tobias Blau, Kathy Keyvani, Laurèl Rauschenbach, Ulrich Sure, Alexander Roesch, Barbara M. Grüner, Björn Scheffler
Format: Artigo
Langue:Inglês
Publié: Elsevier 2024-01-01
Collection:iScience
Sujets:
Health sciences
Pharmacology
Cell biology
Cancer
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S2589004223026731
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