Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors

Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described. Here, we have identified a subset of peptidergic...

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Principais autores:	Vincenzo Prato, Francisco J. Taberner, James R.F. Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A. Heppenstall, Ewan S. Smith, Stefan G. Lechner
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2017-12-01
叢編:	Cell Reports
主題:	nerve growth factor NGF silent nociceptor Piezo2 mechanotransduction inflammatory pain hyperalgesia CHRNA3 mechanically insensitive nociceptor MIA
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211124717317187
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