ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice

Abstract Nuclear clearance and cytoplasmic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) are pathological hallmarks of amyotrophic lateral sclerosis (ALS) and its pathogenic mechanism is mediated by both loss-of-function and gain-of-toxicity of TDP-43. However, the role of TDP-43 gain-of...

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Autori principali:	Mai Horiuchi, Seiji Watanabe, Okiru Komine, Eiki Takahashi, Kumi Kaneko, Shigeyoshi Itohara, Mayuko Shimada, Tomoo Ogi, Koji Yamanaka
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-11-01
Serie:	Acta Neuropathologica Communications
Soggetti:	Amyotrophic lateral sclerosis TDP-43 Oligodendrocyte Myelin Apoptosis Neuroinflammation
Accesso online:	https://doi.org/10.1186/s40478-024-01893-x
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