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Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia

Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol-O-methyltransferase (COMT). Variants of the COMT gene hav...

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Kaydedildi:
Asıl Yazarlar: Marina Sagud, Lucija Tudor, Suzana Uzun, Matea Nikolac Perkovic, Maja Zivkovic, Marcela Konjevod, Oliver Kozumplik, Bjanka Vuksan Cusa, Dubravka Svob Strac, Iva Rados, Ninoslav Mimica, Alma Mihaljevic Peles, Gordana Nedic Erjavec, Nela Pivac
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018-07-01
Seri Bilgileri:Frontiers in Pharmacology
Konular:
treatment-resistant schizophrenia
COMT rs4680 polymorphism
COMT rs4818 polymorphism
COMT rs4680 and rs4818 haplotype
sex-specific association
Online Erişim:https://www.frontiersin.org/article/10.3389/fphar.2018.00705/full
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