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Human PARP1 substrates and regulators of its catalytic activity: An updated overview

Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the amino acid residues of itself or other acceptor p...

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Principais autores: Tao Zhu, Ju-Yan Zheng, Ling-Ling Huang, Yan-Hong Wang, Di-Fei Yao, Hai-Bin Dai
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-02-01
Serier:Frontiers in Pharmacology
Fag:
PARP inhibitors
poly-ADP ribosylation
substrate
DNA damage repair
synthetic lethality
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2023.1137151/full
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