Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody

Phosphatase of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed in a broad range of adult cancer types. However, its physiological expression in pediatric embryonal and mesenchymal tumors and its association with clinical outcomes in children is unknown. We sought to profile the...

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Detalhes bibliográficos

Principais autores:	Amos Hong Pheng Loh, Min Thura, Abhishek Gupta, Sheng Hui Tan, Kelvin Kam Yew Kuan, Koon Hwee Ang, Khurshid Merchant, Kenneth Tou En Chang, Hui Yi Yon, Yong Chen, Mathew Hern Wang Cheng, Arjandas Mahadev, Matthew Chau Hsien Ng, Michaela Su-Fern Seng, Prasad Iyer, Pei Ling Chia, Shui Yen Soh, Qi Zeng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-09-01
coleção:	Molecular Therapy: Oncolytics
Assuntos:	PRL3 PTP4A3, PRL3-zumab pediatric tumors neuroblastoma rhabdomyosarcoma non-rhabdomyosarcoma soft tissue sarcoma
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S237277052300061X
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