Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice

Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver...

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Principais autores:	He Bai, Jian Wen, Jian-Ping Gong, Hao Wu, Fang-Chao Yuan, Ding Cao, Ya-Kun Wu, Xing Lai, Meng-Hao Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2019-05-01
Series:	Autoimmunity
Assuntos:	orthotopic liver transplantation kupffer cells notch1/jagged1 pathway ischemia-reperfusion injury
Acceso en liña:	http://dx.doi.org/10.1080/08916934.2019.1637424
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