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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis

Summary: Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid composition of CD4+ thymus-derived (t)Tregs and Tconvs. Lipidomics reveal constitutive enrichment of neutral lipids in Tconvs and ph...

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Kaydedildi:
Asıl Yazarlar: Sander de Kivit, Mark Mensink, Sarantos Kostidis, Rico J.E. Derks, Esther A. Zaal, Marieke Heijink, Lotte J. Verleng, Evert de Vries, Ellen Schrama, Niek Blomberg, Celia R. Berkers, Martin Giera, Jannie Borst
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2024-09-01
Seri Bilgileri:Cell Reports
Konular:
CP: Immunology
CP: Metabolism
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2211124724010325
Etiketler: Etiketle
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