Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma

Summary: The outcome of immune checkpoint blockade (ICB) therapy largely hinges on the antitumor immunity of tertiary lymphoid structures (TLSs), but drivers of tumor TLS formation remain exclusive. By integrating spatial transcriptomics and a pan-cancer single-cell atlas, we reveal the characterist...

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Egile Nagusiak:	Shang-Xin Liu, Tao-Wei Wu, Dong-Hua Luo, Le-Le Zhang, Lu Zhou, Yi-Ling Luo, Wen-Ting Du, Ting-Ting Huang, Sizun Jiang, Zhe Zhang, Ping Han, Mu-Sheng Zeng, Qian Zhong
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2025-07-01
Saila:	Cell Reports Medicine
Gaiak:	tertiary lymphoid structures high endothelial venules interferon immunotherapy nasopharyngeal carcinoma interferon-responsive high endothelial venules
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2666379125002733
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