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Stoking an anti-liver cancer immune response with cryoablation plus an intratumoral TLR9 agonist and dual checkpoint inhibitors

Abstract The rising incidence of hepatocellular carcinoma (HCC) is partly driven by metabolic dysfunction-associated steatohepatitis (MASH). Recurrence after treatment is high, and advanced disease carries a poor prognosis. The immunosuppressive tumor microenvironment (TME) in HCC limits the efficac...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yunpeng Yang, Tyler Mandt, David Mittelstein, Manasi Das, Panyisha Wu, Mansur A. Ghani, Ritvik Illindala, Nicole F. Steinmetz, Adam M. Burgoyne, Zachary Berman, Nicholas Webster, Isabel G. Newton
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer 2026-02-01
Schriftenreihe:Cancer Immunology, Immunotherapy
Schlagworte:
Hepatocellular carcinoma
Cryotherapy
CpG
Dual checkpoint blockade
Abscopal
Online-Zugang:https://doi.org/10.1007/s00262-025-04286-8
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