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Modulation of the LDL receptor and LRP levels by HIV protease inhibitors

Inhibitors of the human immunodeficiency virus (HIV)-1 protease have proven to be effective antiretroviral drugs. However, patients receiving these drugs develop serious metabolic abnormalities, including hypercholesterolemia. The objective of the present study was to identify mechanisms by which HI...

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Autori principali: Huan Tran, Susan Robinson, Irina Mikhailenko, Dudley K. Strickland
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2003-10-01
Serie:Journal of Lipid Research
Soggetti:
cholesterol
lipids
human immunodeficiency virus
therapy
endoplasmic reticulum stress
proteolysis
Accesso online:http://www.sciencedirect.com/science/article/pii/S0022227520337032
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