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The potential mechanism of celastrol attenuating atherosclerosis by promoting macrophage autophagy via AMPK/ULK1 pathway

BackgroundThis study aimed to elucidate the molecular mechanisms by which celastrol (Cel) alleviates atherosclerosis (AS) through the regulation of macrophage autophagy.MethodsAn AS model was established using ApoE−/− mice fed a high-fat diet. Mice in the treatment group received Cel. Aortic plaque...

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Principais autores: Jiao Li, Yanrong Zhao, Yanfang Qi, Yafang Chen, Yue Liu, Linlin Fang, Zhenying Zhou, Liping Wei, Qi Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-11-01
coleção:Frontiers in Pharmacology
Assuntos:
celastrol
atherosclerosis
macrophage
autophagy
AMPK/Ulk1 pathway
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1700663/full
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