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Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow-inactivation of these channels, suggesting different bi...

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Hoofdauteurs: Julie I. R. Labau, Matthew Alsaloum, Mark Estacion, Brian Tanaka, Fadia B. Dib-Hajj, Giuseppe Lauria, Hubert J. M. Smeets, Catharina G. Faber, Sulayman Dib-Hajj, Stephen G. Waxman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021-12-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
voltage-gated sodium channels
local anesthetics
manual and automated electrophysiolgy
voltage-sensing domain
molecular docking
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2021.791740/full
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