Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation

Internalisation of G protein-coupled receptors (GPCRs) can contribute to altered cellular responses by directing signalling from non-canonical locations, such as endosomes. If signalling processes are locally constrained, active receptors in different subcellular locations could produce different do...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Shiqian Chen, Carolina B. Lobato, Carissa Wong, Yusman Manchanda, Katrina Viloria, Iona Davies, Daniel B. Andersen, Julia Ast, Kyle W. Sloop, David J. Hodson, Johannes Broichhagen, Steve Bloom, Jens J. Holst, Tricia Tan, Alejandra Tomas, Ben Jones
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-01-01
coleção:	Molecular Metabolism
Assuntos:	GLP-1 GPCR Biased agonism Obesity Type 2 diabetes
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221287782500211X
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!