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PHLPP1 inhibits the growth and aerobic glycolysis activity of human ovarian granular cells through inactivating AKT pathway

Abstract Background Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features, and PCOS is associated with infertility. PH domain Leucine-rich repeat Protein Phosphatase 1 (PHLPP1) has been shown to regulate A...

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Hlavní autoři: Xiaoyan Yang, Min A, Tana Gegen, Badema Daoerji, Yue Zheng, Aiming Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-01-01
Edice:BMC Women's Health
Témata:
PHLPP1
Infertility
Polycystic ovary syndrome
Glycolysis
AKT signaling
On-line přístup:https://doi.org/10.1186/s12905-023-02872-5
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