Reducing the Immunogenicity of Pulchellin A-Chain, Ribosome-Inactivating Protein Type 2, by Computational Protein Engineering for Potential New Immunotoxins

Pulchellin is a plant biotoxin categorized as a type 2 ribosome-inactivating protein (RIPs) which potentially kills cells at very low concentrations. Biotoxins serve as targeting immunotoxins (IT), consisting of antibodies conjugated to toxins. ITs have two independent protein components, a human an...

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Bibliographic Details

Main Authors:	Reza Maleki, Libing Fu, Ricardo Sobhie Diaz, Francisco Eduardo Gontijo Guimarães, Otávio Cabral-Marques, Gustavo Cabral-Miranda, Mohammad Sadraeian
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2023-01-01
Series:	J
Subjects:	pulchellin A-chain (PAC) ribosome-inactivating protein (RIPs) immunotoxin (IT) immunogenicity B-cell epitopes molecular docking
Online Access:	https://www.mdpi.com/2571-8800/6/1/6
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