GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements

Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells. In available structures, Lys-295 in the lariat loop of arrestin-3 and its homologue Lys-294 in arrestin-2 directly interact with t...

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Bibliografiska uppgifter

Huvudupphov:	Chen Zheng, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, Vsevolod V. Gurevich
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2023-06-01
Serie:	Cells
Ämnen:	arrestin GPCR JNK3 conformation signaling bias
Länkar:	https://www.mdpi.com/2073-4409/12/12/1563
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