Human Testicular Germ Cells, a Reservoir for Zika Virus, Lack Antiviral Response Upon Zika or Poly(I:C) Exposure

Zika virus (ZIKV) is an emerging teratogenic arbovirus that persists in semen and is sexually transmitted. We previously demonstrated that ZIKV infects the human testis and persists in testicular germ cells (TGCs) for several months after patients’ recovery. To decipher the mechanisms underlying pro...

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Detalhes bibliográficos

Principais autores:	Ohiniba Nadège Kuassivi, Hervé Abiven, Anne-Pascale Satie, Matéo Cartron, Dominique Mahé, Florence Aubry, Romain Mathieu, Valérie Rebours, Anna Le Tortorec, Nathalie Dejucq-Rainsford
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Immunology
Assuntos:	testicular germ cells pathogen recognition receptor (PRR) Zika virus persistence interferon and antiviral effectors human testis innate immunity IRF3
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.909341/full
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