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Local delivery of SBRT and IL-12 to murine PDAC tumors modulates hematopoiesis

Standard of care radiotherapy and chemotherapy have shown limited efficacy in pancreatic ductal adenocarcinoma (PDAC). Immunotherapy has emerged as a promising treatment but has been hindered by systemic toxicities. A shift from systemic to localized delivery has reduced adverse effects and improved...

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Principais autores: Tara G. Vrooman, Emily R. Quarato, Gary Hannon, Noah A. Salama, Maggie L. Lesch, Angela L. Hughson, Vedika S. Chandak, Nataliia Vdovichenko, Zhiming Jin, Ronald Lakony, Jian Ye, Sarah L. Eckl, Sidney Lesser, Edith M. Lord, David C. Linehan, Haoming Qiu, Nadia Luheshi, Jim Eyles, Laura M. Calvi, Scott A. Gerber
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2026-12-01
coleção:OncoImmunology
Assuntos:
Pancreatic ductal adenocarcinoma
hematopoietic stem cells
stereotactic body radiation therapy
interleukin-12, bone marrow
hematopoiesis
Acesso em linha:https://www.tandfonline.com/doi/10.1080/2162402X.2026.2682058
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