Spatial protein expression patterns across pathologically-associated fibers revealed molecular specialization in inclusion body myositis

Abstract Objectives In Inclusion Body Myositis (IBM), myofibers undergo structural and functional changes, including increased regeneration, atrophy, and fibrosis. The molecular mechanisms driving pathologically -associated fibers (PAF) remain poorly understood. Methods We developed a myofiber-level...

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Autors principals:	T. I. Nijssen, S. Davis, R. A. O’Shaughnessy, E. Bos, A. J. van der Kooi, J. Raaphorst, E. Aronica, R. Fischer, B. M. Kessler, Vered Raz
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Cell Communication and Signaling
Matèries:	Inclusion body myositis Spatial proteomics Pathogenesis-associated myofibers Regenerative myofibers Histopathology
Accés en línia:	https://doi.org/10.1186/s12964-026-02720-7
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