Improving the efficiency of drug resistant tuberculosis treatment trials: a time-to-event alternative marker for bacteriological response and adaptive minimization for randomization

Abstract Background Establishing the efficacy of new treatments for rifampicin-resistant tuberculosis (RR-TB) is challenging due to the long-term clinical endpoints of two-year relapse-free survival. This study aimed to evaluate the effect of an alternative indicator of treatment response on sample...

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Detaylı Bibliyografya

Asıl Yazarlar:	Elise De Vos, Annelies Van Rie, Steven Abrams
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	BMC 2025-11-01
Seri Bilgileri:	BMC Medical Research Methodology
Konular:	Sample size Tuberculosis, Multidrug-Resistant Clinical trial, phase III Epidemiologic methods Random allocation, epidemiologic research design
Online Erişim:	https://doi.org/10.1186/s12874-025-02697-w
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