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TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas

Background & Aims: Acinar-to-ductal metaplasia (ADM) serves as a precursor event in the development of pancreatic ductal adenocarcinoma (PDAC) upon constitutive environmental and genetical stress. While the role of ADM in PDAC progression has been established, the molecular mechanisms underlying hum...

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Principais autores: Michael Nipper, Yi Xu, Jun Liu, Xue Yin, Zhijie Liu, Zhengqing Ye, Jianmin Zhang, Yidong Chen, Pei Wang
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2024-01-01
סדרה:Cells
נושאים:
acinar-to-ductal metaplasia
ATAC-seq
ChIP-Seq
Hippo pathway
TGFβ signaling
גישה מקוונת:https://www.mdpi.com/2073-4409/13/2/186
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