Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity

Abstract Peptide-activated G protein-coupled receptors (GPCRs) play crucial roles in numerous diseases, but remain difficult therapeutic targets due to the challenges in developing small-molecule drugs. Here, we explore structure-based strategies to identify small-molecule agonists of neurotensin (N...

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Үндсэн зохиолчид:	Nicolas Panel, Duy Duc Vo, Harald Hübner, Mattia Deluigi, Szymon Pach, Félix Bélair, Dorothee Weikert, Christoph Klenk, Mark Hilge, Niharika Shiva, Isabelle Brochu, Jean-Michel Longpré, Frida Bällgren, Aljona Saleh, Huabin Hu, Jon Kapla, Stefanie Kampen, Israel Cabeza de Vaca, Jan Kihlberg, Nina Wettschureck, Philippe Sarret, Andreas Plückthun, Peter Gmeiner, Jens Carlsson
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2026-07-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-026-74990-1
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!