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Modulation of RNA primer formation by Mn(II)-substituted T7 DNA primase

Abstract Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA primase. The N-terminal primase domain of the gene 4 protein of phage T7 comprises a zinc-binding domain that recognizes a specific DNA sequence and an RNA polymerase domain that catalyzes RNA polymerization...

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Autori principali: Stefan Ilic, Sabine R. Akabayov, Roy Froimovici, Ron Meiry, Dan Vilenchik, Alfredo Hernandez, Haribabu Arthanari, Barak Akabayov
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2017-07-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-017-05534-3
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