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Myostatin Regulates Inflammatory Cytokine and Chemokine Expression, Rheumatoid Arthritis Synovial Fibroblast Invasion, and CD4<sup>+</sup> Th Cell Transmigration

Rheumatoid arthritis synovial fibroblasts (RASFs) play a pivotal role in joint destruction in RA. Myostatin (MSTN), a myokine, is highly expressed in the RA synovium; however, its role in the function of RASFs is unclear. We hypothesized that MSTN amplifies inflammatory cytokines/chemokines, promote...

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Main Authors: Samudra Lansakara, Janis Weis, Chathura Siriwardhana, Yongsoo Kim
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-09-01
Series:Immuno
Subjects:
myostatin
rheumatoid arthritis
synovial fibroblasts
cytokines
chemokines
Online Access:https://www.mdpi.com/2673-5601/5/3/42
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