Small-molecule compound from AlphaScreen disrupts tau-glycan interface
Tauopathies are neurodegenerative diseases characterized by intracellular abnormal tau deposits in the brain. Tau aggregates can propagate from one neuron to another in a prion-like manner, mediated by the interaction between tau and cell surface heparan sulfate proteoglycans. We developed an AlphaS...
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| Principais autores: | , , , , , , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
Frontiers Media S.A.
2022-12-01
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| 丛编: | Frontiers in Molecular Biosciences |
| 主题: | |
| 在线阅读: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1083225/full |
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