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Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence

IntroductionPolymorphisms in the KIR and HLA genes contribute to the diversity of the NK cell repertoire. Extrinsic factors also play a role in modifying this repertoire. The best example is cytomegalovirus, which promotes the expansion of memory-like NK cells. However, the mechanisms governing this...

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Principais autores: Enora Ferron, Gaëlle David, Catherine Willem, Nolwenn Legrand, Perla Salameh, Laetitia Anquetil, Alexandre Walencik, Ketevan Gendzekhadze, Katia Gagne, Christelle Retière
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-04-01
Serier:Frontiers in Immunology
Fag:
KIR
HLA
NK cells
repertoire
CMV
CD57
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1389358/full
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