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Cytogenomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals TCR rearrangements as predictive factors for exceptional prognosis

Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) represents a rare and clinically and genetically heterogeneous disease that constitutes 10–15% of newly diagnosed pediatric ALL cases. Despite improved outcomes of these children, the survival rate after relapse is extremely poor. Moreo...

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Hlavní autoři: Libuse Lizcova, Eva Prihodova, Lenka Pavlistova, Karla Svobodova, Ester Mejstrikova, Ondrej Hrusak, Pavla Luknarova, Iveta Janotova, Lucie Sramkova, Jan Stary, Zuzana Zemanova
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2024-05-01
Edice:Molecular Cytogenetics
Témata:
Comprehensive cytogenomic analysis
Pediatric T-ALL
TCR aberrations
Prognostic factors
On-line přístup:https://doi.org/10.1186/s13039-024-00682-4
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