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The aryl hydrocarbon receptor is associated with monocytic AML and innate immune resistance reversible with an AHR inhibitor

BackgroundAcute myeloid leukemia (AML) is characterized by a complex interplay between genomic alterations, aberrant hematopoiesis, and immune evasion. The aryl hydrocarbon receptor (AHR) pathway is a critical player in this phenomenon determining the fate of stem cell differentiation as well as dic...

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Main Authors: Jennifer N. Saultz, Daniel Bottomly, Faith Burns, Kaelan Byrd, Yoko Kosaka, Bernhard Alber, Daniel Chandra, Stephen E. Kurtz, Guang Fan, Andy Kaempf, Nicola Long, Marta Sanchez-Martin, Lei Wang, Karen McGovern, Dan S. Kaufman, Shannon K. McWeeney, Brian J. Druker, Jeffrey W. Tyner, Evan F. Lind
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-12-01
Series:Frontiers in Immunology
Subjects:
leukemia
immunotherapy
NK cells
AhR
AML
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554166/full
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