Fc gamma receptor binding modulates IgG clearance in cancer cachexia

BackgroundPatients with cancer-cachexia display a general resistance to Immune Checkpoint Inhibitor (ICI) therapy, as well as an elevated baseline catabolic clearance (CL) of ICIs, which serves as a prognostic indicator of overall survival independent of dose and drug exposure. Increased rate of ICI...

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Opis bibliograficzny

Główni autorzy:	Bryan C. Remaily, Kyeongmin Kim, Justin Thomas, Adeoluwa Adeluola, Greg Young, Min Hai, Mayu Fukuda, Gillian Mulcahy, Camille Stanton, Lauren Granchie, Pankaj Kumar, Trang Vu, Faith Jeffrey, Noah Palozzi, Xiaokui Mo, Samuel K. Kulp, Dwight H. Owen, Thomas A. Mace, Christopher C. Coss, Mitch A. Phelps, Latha P. Ganesan
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2026-03-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	antibody pharmacology cancer cachexia catabolic clearance Fc receptors FcγR immune checkpoint inhibitors
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1676732/full
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