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Humanization of yeast genes with multiple human orthologs reveals functional divergence between paralogs.

Despite over a billion years of evolutionary divergence, several thousand human genes possess clearly identifiable orthologs in yeast, and many have undergone lineage-specific duplications in one or both lineages. These duplicated genes may have been free to diverge in function since their expansion...

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Principais autores: Jon M Laurent, Riddhiman K Garge, Ashley I Teufel, Claus O Wilke, Aashiq H Kachroo, Edward M Marcotte
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Biology
Acceso en liña:https://doi.org/10.1371/journal.pbio.3000627
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