Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.

The molecular factors and genetic adaptations that contributed to the emergence of Mycobacterium tuberculosis (MTB) from an environmental Mycobacterium canettii-like ancestor, remain poorly investigated. In MTB, the PhoPR two-component regulatory system controls production and secretion of proteins...

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Detalhes bibliográficos

Principais autores:	Wladimir Malaga, Delphine Payros, Eva Meunier, Wafa Frigui, Fadel Sayes, Alexandre Pawlik, Mickael Orgeur, Céline Berrone, Flavie Moreau, Serge Mazères, Jesus Gonzalo-Asensio, David Rengel, Carlos Martin, Catherine Astarie-Dequeker, Lionel Mourey, Roland Brosch, Christophe Guilhot
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2023-07-01
coleção:	PLoS Pathogens
Acesso em linha:	https://doi.org/10.1371/journal.ppat.1011437
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