Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes

Abstract Background The link between cardiac diseases and cognitive deterioration has been accepted from the concept of “cardiogenic dementia”, which was proposed in the late 1970s. However, the molecular mechanism is unclarified. Methods The two animal models used in this study were cardiac-specifi...

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Hlavní autoři:	Ming-Jing Duan, Mei-Ling Yan, Qin Wang, Meng Mao, Dan Su, Lin-Lin Sun, Ke-Xin Li, Yang Qu, Qiang Sun, Xin-Yu Zhang, Si-Yu Huang, Ji-Chao Ma, Tao Ban, Jing Ai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-11-01
Edice:	Cell Communication and Signaling
Témata:	Heart Hippocampus Synaptic vesicle exocytosis microRNA-1 SNAP-25
On-line přístup:	http://link.springer.com/article/10.1186/s12964-018-0303-5
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