Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism

Despite the discovery of the tubercle bacillus more than 130 years ago, its physiology and the mechanisms of virulence are still not fully understood. A comprehensive analysis of the proteomes of members of the human-adapted Mycobacterium tuberculosis complex (MTBC) lineages 3, 4, 5, and 7 was condu...

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Autori principali:	Solomon Abebe Yimer, Shewit Kalayou, Håvard Homberset, Alemayehu Godana Birhanu, Tahira Riaz, Ephrem Debebe Zegeye, Timo Lutter, Markos Abebe, Carol Holm-Hansen, Abraham Aseffa, Tone Tønjum
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-09-01
Serie:	Frontiers in Microbiology
Soggetti:	Mycobacterium tuberculosis lineage 7 proteomics DNA repair ESX-3 secretion system virulence
Accesso online:	https://www.frontiersin.org/article/10.3389/fmicb.2020.550760/full
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