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IL-15 functionalized biomimetic hybrid mRNA vaccine for enhanced NSCLC immunotherapy via synergistic activation of T cells and NK cells

CD8+T cells-based mRNA vaccines represent a promising strategy for cancer immunotherapy. However, their development is significantly limited by the low-expression of major histocompatibility complex (MHC) I on tumor cells, which impairs effective antigen presentation and T cells recognition. Given t...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Jueshuo Guo, Li Peng, Penglong Ma, Yaping Mai, Ting Gao, Na Yu, Wenbao Zuo, Jianhong Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-06-01
Schriftenreihe:Materials Today Bio
Schlagworte:
mRNA vaccine
IL-15
Immunotherapy
Lung cancer
Biomimetic hybrid
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2590006425004843
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