Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.

Canonical Wnt signaling is controlled intracellularly by the level of β-catenin protein, which is dependent on Axin scaffolding of a complex that phosphorylates β-catenin to target it for ubiquitylation and proteasomal degradation. This function of Axin is counteracted through relocalization of Axin...

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Bibliografski detalji

Glavni autori:	Marinella G Callow, Hoanh Tran, Lilian Phu, Ted Lau, James Lee, Wendy N Sandoval, Peter S Liu, Sheila Bheddah, Janet Tao, Jennie R Lill, Jo-Anne Hongo, David Davis, Donald S Kirkpatrick, Paul Polakis, Mike Costa
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2011-01-01
Serija:	PLoS ONE
Online pristup:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022595&type=printable
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