Baicalein inhibits amyloid beta42 aggregation through disruption of the Asp23-Lys28 salt bridge

Abstract The aggregation of amyloid beta-42 (Aβ42) into β-sheet-rich fibrillar structures is a critical pathogenic feature of Alzheimer’s disease (AD). Baicalein (BCN), a natural flavonoid, has been shown to inhibit aggregation in amyloidogenic proteins, including human islet amyloid polypeptide (hI...

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Autors principals:	Faisal Nabi, Owais Ahmad, Mohammad Rehan Ajmal, Mohd Amir, Iram Parveen, Fahad M. Almutairi, Rizwan Hasan Khan
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-10-01
Col·lecció:	Scientific Reports
Matèries:	Alzheimer’s disease Amyloid beta42 Baicalein Protein aggregation Molecular simulations
Accés en línia:	https://doi.org/10.1038/s41598-025-21991-7
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