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An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes

The ability to produce unlimited numbers of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) harboring disease and patient-specific gene variants creates a new paradigm for modeling congenital heart diseases (CHDs) and predicting proarrhythmic liabilities of drug candidates. Ho...

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Principais autores: Wesley L. McKeithan, Alex Savchenko, Michael S. Yu, Fabio Cerignoli, Arne A. N. Bruyneel, Jeffery H. Price, Alexandre R. Colas, Evan W. Miller, John R. Cashman, Mark Mercola
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-10-01
coleção:Frontiers in Physiology
Assuntos:
induced pluripotent stem cells
cardiomyocyte
voltage sensitive probe
high throughput screening
drug development
cardiotoxicity
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphys.2017.00766/full
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