Integrated PBPK-EO modeling of osimertinib to predict plasma concentrations and intracranial EGFR engagement in patients with brain metastases

Abstract The purpose of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model combined with an EGFR occupancy (EO) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and the intracranial time-course of EGFR (T790M and L858R mutants) eng...

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Bibliografische Detailangaben

Hauptverfasser:	Feng Liang, Yimei Zhang, Qian Xue, Xiaoling Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-06-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Osimertinib PBPK-EO model Appropriate dosing regimens DDIs
Online-Zugang:	https://doi.org/10.1038/s41598-024-63743-z
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